Projects

Predicting age-related mobility impairments. (NWO Rubicon personal grant Aug 2018- Aug 2020)

Age-related mobility impairments resulting from progressive movement limitations pose societal and economic burdens on our population. Ageing is accompanied by loss of physical properties such as muscle strength and power, bone health, and (joint)pain, for which elderly develop coping mechanisms in their movement strategies. Furthermore, movement strategies are influenced by preferences in movement objectives, in terms of avoidance of risk (stability, speed) and pain, as well as energy efficiency. However, scientists and clinicians do not yet fully understand the effects of decline of each individual physical property and movement objective, on the movement strategies of elderly, since only their combined actions can be observed. Therefore, it is unknown how much decline of each variable can be tolerated before daily activities become impaired, which impedes developments of (preventive) therapies. The aim of my study is to determine these individual and combined effects of decline, using a dynamic computational model that can quantitatively predict (simulate) how human movement strategies change as a result from progressively changing age-related physical properties and movement objectives. I will develop predictive neuro-musculoskeletal models adjusted to ageing to perform these simulations. My models can support clinicians in prescribing more effective and efficient treatment to prolong mobility in elderly.

Stage 1: Development of musculoskeletal (MSK) models of elderly To apply and develop a forward dynamic framework for the simulation of elderly, I will develop an ageing model of the decline for separate physical variables.

{The following is adopted from our article: “CaReMoOC: Capacity, Reserve, Movement Objectives, and Compensation. A new framework to describe mechanisms of movement limitations, demonstrated for ageing.” which is currently in review at European Reviews of Aging and Physical Activity}

Our locomotion system is made up of our neural, muscular, and skeletal system. Over the course of our life we develop these systems, building our neuromusculoskeletal capacity. This increase in capacity can be compared to charging a battery (a capacitor). Charging a battery requires an active source, which is comparable to an active lifestyle. The time it takes to charge the battery is determined by environmental effects and lifestyle choices such as nutrition, drug and/or alcohol use, and illnesses (resistors), and our genetics (capacitance value). Genetics together with the active source determine the maximum amount we can charge our battery (capacitor value).

Decline of neuromusculoskeletal (NMSK) capacity is a result of structural changes of the neural, muscular, and skeletal (including soft tissues) systems. The onset of this decline is different between people and between elements of our capacity but starts already in our mid-twenties.

We usually don’t notice the onset of capacity decline as our bodies are redundant. Reserve is the difference between our capacity and the task demand. As task requirements vary over the duration of the task, so does reserve, therefore, inability may occur for only a portion of the task.

Within the redundancy of capacity and reserve, humans both consciously and unconsciously decide on movement strategies. The applied motion strategy of humans considers metabolic energy, speed, safety (e.g. stability margins), and/or pain avoidance, which will be jointly referred to as the movement objectives. For example, an Olympic speed skater wants to win the race and consciously puts most emphasize on velocity, ignoring pain. However, in daily life, we walk at a speed that is as energy efficient as possible, to increase endurance. The movement objectives and their relative weighting are a multi-objective function determining the most effective strategy. Humans make comparative assessments of movement objectives based on the task goal, their capacity, and psychological reasons such as fear of falling, pain, or an unknown environment.

A compensatory movement strategy is defined as compensation in relation to a baseline (e.g. previous state or a control group). Two levels of compensation are:

  • Compensation by selection: people can complete tasks using a variety of strategies to retain mobility including upper limb to lower limb compensations and postural changes. Compensation by selection is a variation in the planned movement trajectory. This compensation strategy is observable and can be expressed with the kinematics of the motion. Examples of compensation by selection are using the arms for standing up, using the handrail when climbing stairs, walking with a walking aid, widening the base of support in gait, or running with shorter step lengths.
  • Compensation by reorganization: this form of compensation engages the altered selection of muscle recruitment. This form of compensation co-occurs when compensation by selection is apparent. However, as there is a redundancy in the muscle architecture of the human body, compensation by reorganization can also occur without a change in trajectory. A possible need of reorganization in healthy ageing could be the relative difference in decline of muscle strength between muscle groups. An example of this form of compensation is co-contraction, which is a strategy that can be executed to increase stability through changes only in muscle recruitment, rather than changes in kinematics.

In my model I incorporate changes in the muscular system and the neural system by changing the parameters of the model. The hearing, visual, and vestibular system are currently not incorporated. The changes in the skeletal system are represented by altered weighting of movement objectives: cartilage degeneration results in joint pain, whereas bone mineral density and morphological changes result in increased fear of falling (emphasize on stability) due to the increased consequences of a fall. Moreover, altered body mass distribution and reduced joint range of motion are incorporated in the parameters of the model.

Stage 2: Use predictive simulations to determine the effect of ageing mechanisms on movement strategy The ageing musculoskeletal model will be implemented in existing forward simulation platforms (OpenSim, Scone). 

{The following is adopted from our article: “The effect of ageing on the standing up movement analysed using the Capacity, Reserve, Movement Objectives, and Compensation (CaReMoOC) framework” which is currently in review at European Reviews of Aging and Physical Activity}

Prolonging independence for older adults is a major concern for our ageing societies (UN, 2019).  One of the more important movements in daily-life is standing up, for example, getting up from a chair, getting out of bed, or leaving the toilet. When standing up can no longer be performed independently, then in-home care or moving to a care facility is required. There are moderate relationships between strength and rising strategy, however, it is also clear that strength is not the only contributing factor. Most experimental studies have studied this movement in restricted experimental set-ups (no arm aid, symmetric foot positioning, standing still after standing up), not allowing for compensation strategies. Moreover, most studies looked at isolated variables of capacity (mostly muscular, neglecting neural and skeletal decline), therefore other relevant factors that might interact with the compensation strategies identified in these studies cannot be ruled out.

{The following are preliminary results from the predictive simulations; the optimizations are still ongoing}
Predictive neuromusculoskeletal models can quantitatively predict (simulate) how human movement strategies change as a result from progressively changing age-related physical properties and movement objectives. This work is in progress, but the first steps have been taken. To start of the predictive modelling, I used an OpenSim healthy male adult lower limb model and the Scone Software (Thomas Geijtenbeek). In these first simulations, the model learns to perform a standing up movement and initiates walking from a standing position. The model is currently being updated to incorporate a lumbar joint and trunk muscles. Moreover, the model is used in optimizations to perform a fluent sit-to-walk movement. Next, the model will be aged to look into age-related compensation strategies.

 

Stage 3: Verify the forward simulation results The simulated movement strategies will be compared to measured movement strategies of elderly.

On Friday Nov 8th 2019 we had our 50th, and for now last, participant in the lab for our 4-hour motion caption study for validation purposes. Next step is to process all these data and analyse the results!


 

Stage 4: Visualization of the optimizations Since the scope of my project is aimed at the clinical applicability of the results, I will visualize the results in an online open-source interactive user-interface visualization tool applicable for clinical specialists